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How does Propecia (Finasteride) act on the body of a man? #
Scientists have proved that such common problem as a male alopecia is related to the changed level of the male sexual hormones. To treat this disease, a pharmaceutical drug Propecia is used.
Most men think that Propecia is a hormonal drug, and so they are afraid to start the treatment because most hormonal products have side effects and should not be taken for a long period.
Infact, Propecia is not a hormonal drug. In order to sort out how Propecia acts on the body of a man, it is necessary to know why alopecia occurs.
The male sexual hormones are responsible for the hair growth. The basic hormone is testosterone. This hormone turns into dihydrotestosterone due to 5-alpha-reductase enzyme. This is a biologically active form of testosterone which actively binds to the androgenic receptors of the tissues, so that it has a broad action.
A concentration of dihydrotestosterone influences on the growth or loss of hair. Due to the internal changes, a concentration of the androgenic hormones may grow, so that the hair growth is increased on the body, or the hair loss may begin.
The hair follicles on the head have another type of receptors which are more sensitive to the action of dihydrotestosterone. As a result, these hair follicles lose an ability to produce hair, and alopecia begins.
The main active ingredients of Propecia is Finasteride. This ingredient has one task – to block special enzyme 5-alpha-reductase of the second type that is able to transform testosterone. 1 mg Finasteride can block 5-alpha-reductase in order to reduce the concentration of dihydrotestosterone by 76%.
It means that the use of Propecia causes a reduction of the androgenic hormone level. But Finasteride is not a hormonal product because it does not act on hormones. The drug activates a complicated chain of enzymes through which the production of dihydrotestosterone is blocked.
Therefore, FDA has proved a high pharmacological safety of Propecia (Finasteride) and approved the drug to treat alopecia.
5-alpha-reductase type 2 is absent on other parts of the skin, and therefore Finasteride is not able to act on the hair growth except frontal and parietal parts. That is why, hair grow only on the head during the use of the drug. And hair is lost on the head only.
Reaching the body, Propecia regulates the level of dihydrotestosterone, so that the level of testosterone slightly grows. Due to these processes, the normal balance of the male sexual hormones is restored, and alopecia is treated within several months.
A change of the hormone level does not cause any complications or disorders because the drug helps to restore a normal functioning. Propecia (Finasteride) does not favor atypical change of the male sexual hormone level, and therefore it is completely safe.
The effect from the use of the pill is kept within 2 weeks. But in spite of this, the drug should be taken every day in order to control a therapeutic action. After the end of the drug use, Finasteride is completely excreted from the body within 2 weeks, and the functioning of all receptors and enzymes will be restored.
If the level of dihydrotestosterone grows again after the end of the use of the pills, a man should restore the treatment.
Propecia does not cause irreversible effects. The action is kept only during the use of the pills, and then the body itself regulates the work of all parts of the endocrine system.