Get Phentermine for Weight Loss Prescribed Online

Phentermine is a prescription medication approved for short-term use as an adjunct to a reduced-calorie diet and increased physical activity for weight loss in individuals with obesity. It is a sympathomimetic amine, similar to an amphetamine, and works by suppressing appetite through central nervous system stimulation.

Phentermine is typically prescribed for patients with a body mass index (BMI) of 30 or higher, or 27 or higher with weight-related comorbidities such as hypertension, diabetes, or hyperlipidemia. It is available in several forms, including tablets and capsules, in doses ranging from 8 mg to 37.5 mg. The drug is usually taken once daily, either before breakfast or 1-2 hours after eating, and late evening doses should be avoided due to the risk of insomnia.

Phentermine is classified as a Schedule IV controlled substance because of its potential for abuse and dependence. Prescribers should assess a patient’s cardiovascular health before starting therapy, as the drug can elevate blood pressure and heart rate.

It is contraindicated in patients with a history of cardiovascular disease, hyperthyroidism, glaucoma, or drug abuse. Phentermine should not be used during pregnancy or breastfeeding. Treatment duration typically does not exceed 12 weeks, and abrupt discontinuation should be avoided to reduce withdrawal symptoms.

Phentermine is an amphetamine derivative drug. The history of Phentermine contains many ups and downs. Initially, like many drugs with narcotic potential, the drug was not sufficiently studied but was already put into practice. The drug was first approved in 1959. Like most amphetamines, Phentermine has appetite-suppressant effects. This medicinal substance attracted widespread attention only in 1980. Then Phentermine was first used in combination with Fenfluramine.

This combination showed even higher efficiency than the use of drugs separately. The use of such a mixture was many times more effective than a traditional diet or exercise, which attracted nutritionists and patients.

The drug is available in tablets and capsules. The main route of administration of the drug is oral. Usually, the drug is prescribed before meals or 1-2 hours after. A single dose is most often one tablet or capsule taken in the morning.

Sometimes nutritionists advise starting with half a tablet to see the effectiveness of the drug and the patient’s predisposition to treatment. Less commonly, the drug is prescribed 2-3 times a day, but the last dose should not be taken later than 4-5 hours before bedtime. The course of treatment usually lasts from 2 to 4 weeks. In rare cases, when therapy progresses slowly, therapy can be extended up to 12 weeks.

Mechanism of action of Phentermine #

Phentermine, like all amphetamines, is a central stimulant. Phentermine is also a sympathomimetic, that is, a substance that can activate sympathetic nerve fibers. The chemical structure of Phentermine is very similar to amphetamine; according to the chemical nomenclature, the drug is called 2-methyl-amphetamine.

All amphetamines act by activating the release of catecholamines. These are hormones, that is, special protein molecules that have high physiological activity.

Such molecules act as biological mediators that control intercellular interactions and activate or inhibit various processes in the body. Catecholamines include dopamine, norepinephrine, adrenaline and some others.

By increasing the release of such substances, many processes are activated in the human body. Lipolysis increases, glucose consumption increases, and excitement occurs in the central nervous system and peripheral nervous system. Amphetamines can cause many effects.

This group of drugs was used during the war to improve the performance of soldiers. Under the influence of amphetamines, people stop feeling fear, and the sense of self-preservation disappears.

Phentermine most actively increases the content of norepinephrine in the blood and has a lesser effect on the exchange of serotonin and dopamine.

It is the increased content of norepinephrine that affects the center of hunger and satiety, located in the ventromedial and ventrolateral nuclei of the hypothalamus. Norepinephrine reduces the production of a neuropeptide that causes hunger and provokes the accumulation of adipose tissue.

In addition to norepinephrine, the amount of adrenaline in the blood also increases. This hormone accelerates lipolysis, that is, the breakdown of fat. In addition, adrenaline significantly increases physical activity, which also helps burn fat and excess calories.

Side effects and contraindications #

Phentermine, due to its action, is contraindicated in many conditions and diseases. At the same time, this drug has a detrimental effect on the cardiovascular system, which is most often already damaged in overweight people.

It is also impossible to use Phentermine in patients who have:

• eating disorders, psychological disorders,
• arterial hypertension syndrome,
• heart failure of the right and left departments,
• atherosclerosis and coronary heart disease,
• thrombosis and phlebitis,
• cerebrovascular accidents,
• aneurysm and vascular erosion,
• history of migraines,
• epilepsy,
• allergic reactions,
• renal and liver failure,
• some hormonal disorders.

Nutritionists often neglect this prohibition since weight loss is often the key to getting rid of pathologies of the cardiovascular, nervous, and hepatobiliary systems.

Since the drug affects the exchange of norepinephrine and adrenaline, the effects of these hormones become enhanced. The side effects of Phentermine are countless. It was this argument that forced this drug to be added to the list of prohibited substances, in addition to developing addiction.

The most common side effects of Phentermine include arrhythmia, critical increase in pulse rate, dehydration, and fluid loss, numbness in the limbs and face, increased excitability of the nervous system, aggressiveness, anxiety, tremors, sleep disturbances, nightmares, arterial hypertension, valvular defects heart, heart failure.

It is impossible to use Phentermine in combination with hypoglycemic agents since the development of hypoglycemic coma is possible.